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James Ho est responsable d'Animoca Ventures. Depuis qu'il a rejoint Animoca Group en 2018, James a directement géré ou initié des investissements précoces dans de nombreuses entreprises Web3 (notamment Yield Guild Games, Opensea, Magic Eden, Matic et Immutable X). Bon nombre de ces entreprises sont aujourd'hui des géants de l'espace Web3, et plusieurs d'entre elles ont atteint le statut de licorne.